Knowlton Lab Translational Statistical Science

Massey University & University of Auckland — one integrated cohort

Statistical methods with a line of sight to clinical impact.

Methods that survive messy data. Proven in the clinic.

Breast cancer risk modelling, endocrine therapy adherence, embryo selection AI, and reproducible research methods — from statistical problem to clinical decision.

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What the lab is working on

active streams
Breast cancer

Can a risk model survive messy screening data?

Multi-modality imaging evaluation, nationwide HER2-Low cohort analysis, breast density AI, and Wāhine Māori health equity.

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Reproductive AI

Can machine learning rank embryos better than an embryologist?

Morphokinetic stage detection, embryo annotation and segmentation, and cohort-relative ranking behind WyldBloom's clinic tools.

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Fertility practice impact

Can AI and automation reduce IVF transfer burden and reclaim embryologist time?

Cohort-relative embryo ranking and lab automation tools now running in NZ fertility clinics.

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Reproducibility

Can a method be trusted if no one can reproduce it?

Open tools and workflows that make translational research auditable from raw data to published conclusion.

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Read the full research cases →
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Research that left the building

WyldBloom
Microscopy image of a developing human embryo

Research into practice · WyldBloom

Making embryo development measurable.

AI, imaging, and clinical decision support turn embryo development into structured, traceable observations — supporting judgement rather than replacing it.

Visit WyldBloom ↗
AI-derived morphology · developmental observations
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One cohort, two institutions

selected people
Hooman MisaghiPhD · Auckland

“Artificial Intelligence Enabled IVF”

Reihaneh HosseiniPhD · Massey

“AI-driven breast cancer screening equity for Aotearoa”

Yuqi DuanPhD · Auckland

“Epidemiology of early-onset cancers with a focus on breast cancer”

Yuting YangPhD · Auckland

“Histological and molecular subtypes of breast cancer in NZ women”

Meet the full cohort →
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Selected work

tagged by where it landed
View publications →
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Join the lab

If a method can't survive messy data, it doesn't belong in the toolkit.

I take students who want to build things that leave the building.

How to join →