Knowlton Lab Translational Statistical Science

Research

Research

Clinical questions, statistical methods, and where the work landed.

01 · Breast cancer

Can a risk model survive messy screening data?

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Clinical problem

Screening data combine different modalities, referral patterns, clinical contexts, and population-level inequities.

Statistical method

Risk modelling, population cohort analysis, explainable imaging AI, and deployment-aware validation.

Where it landed

Led the analysis for the 30,000 Voices national breast cancer report, which shaped ~half of NZ's national breast cancer KPIs.

02 · Reproductive AI

Can machine learning rank embryos better than an embryologist?

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Clinical problem

Embryo assessment is information-rich, time-sensitive, and difficult to make consistently measurable.

Statistical method

Computer vision turns time-lapse imagery into traceable morphology, timing, expansion, and transition measurements.

Where it landed

Patent-pending WyldBloom decision-support tools, international validation, and clinic-pilot workflows.

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03 · Fertility practice impact

Can AI and automation reduce IVF transfer burden and reclaim embryologist time?

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Clinical problem

Embryo selection is subjective, time-pressured, and burdened by manual paperwork that scales poorly across clinics.

Statistical method

Patent-pending cohort-relative embryo ranking on a 45K-embryo, hardware-agnostic dataset, plus lab automation reducing transfers and administrative load.

Where it landed

Patent-pending embryo ranking and lab automation tools now running in NZ fertility clinics, reducing transfers and reclaiming embryologist time.

04 · Reproducibility

Can a method be trusted if no one can reproduce it?

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Clinical problem

Biomedical results lose value when the path from data to conclusion cannot be inspected or repeated.

Statistical method

Reproducible workflows, transparent validation, interactive statistics tools, and explicit assumptions.

Where it landed

Open-source practice and teaching resources for PCA, collinearity, regression, and applied research.